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KMID : 0381319810200030065
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Korean Journal of Occupational Health
1981 Volume.20 No. 3 p.65 ~ p.71
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Urinary Lead Excretion Under Various Dosage Schedule of Oral D-penicillamine
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Abstract
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2,3-Dimercapto-1-propanol (BAL), edathamil calcium disodium (Ca-EDTA) and d-penicillamine (D-PCA) are three typical chelating agents in the treatment of lead poisoning.
Of these, D-PCA is relatively non-toxic and it´s oral efficacy provides a definite advantage, particularly for the long periods of "be-leading" that are often required in lead poisoning.
In order to observe the effect of various dosage schedule of oral D-PCA on urinary lead excretion (ULE), 200~1200㎎ of oral D-PCA were administered on 90 lead patients for 5 days according to the dosage schedule and 24-hour ULE before and during D-PCA administration were measured by dithizon method.
The results were as follows;
1. Five-day average daily ULE increased by approximately 2 to 5 times after daily oral D-PCA of 200~1200㎎ as compared with initial excretion.
Even with 200㎎ per day, significant increase of ULE was noted.
2. With the same daily dose, ULE was observed, as the higher single dose was given less often.
3. Of all 9 groups, 400㎎ b.i.d. and t.i.d. groups showed on largest ULE, reaching 4~5 times as compared with initial excretion.
4. Increment of ULE was largest on the 1st day, decreased gradually as D-PCA administration proceeded, and showed the significant fall on 5th day.
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